What database is HPA?

This article mainly introduces what HPA is a database, has a certain reference value, interested friends can refer to, I hope you can learn a lot after reading this article, the following let the editor take you to understand it.

HPA, whose full name is Human Protein Atls, uses transcriptome and proteomics techniques to study protein expression in different human tissues and organs at the RNA and protein levels.

Https://www.proteinatlas.org/

According to the RNA_seq data of protein coding genes in 32 different tissues, the genes are classified. The results are as follows.

In view of the important role of secretory proteins and membrane-associated proteins in pathophysiology, proteins are divided into different categories shown in the following figure.

Based on the RNA_seq data of different tissues, the enrichment of protein coding genes in different tissues was analyzed, as shown below.

It can be seen that the membrane cantaloupe protein is more in the brain tissue, but more protein is secreted in the lung. In addition to the comparative analysis of protein expression in different tissues / cells, the protein expression in different tumors was further studied.

In HPA, it is further divided into the following three subcategories

1. The Tissus Atlas

Used to view and analyze the expression of protein-coding genes in different tissues and organs. Take MYL7 as an example, the link is as follows

Https://www.proteinatlas.org/ENSG00000106631-MYL7/tissue

The results are as follows

2. The Cell Atlas

The expression of protein coding genes in different cell lines is provided, and the corresponding subcellular localization information is also used. Take CCNB1 as an example, the link is as follows

Https://www.proteinatlas.org/ENSG00000134057-CCNB1/cell

The results are as follows

3. The Pathology Atlas

It provides the gene expression in tumor tissue, as well as survival analysis, pathological images and other results. Take MK167 as an example, the link is as follows

Https://www.proteinatlas.org/ENSG00000148773-MKI67/pathology

The results are as follows

Through the HPA database, we can easily explore the expression of protein-coding genes in normal and tumor tissues / organs.

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