What is the use of DGV database
Editor to share with you what is the use of DGV database, I believe most people do not know much about it, so share this article for your reference, I hope you can learn a lot after reading this article, let's go to know it!
The DGV database contains the information of genomic structure changes greater than 50bp in healthy samples.
The web address of the database is as follows
Http://dgv.tcag.ca/dgv/app/home
Search the corresponding research results of normal samples from two large genome structure variation databases, NCBI dbVar and EBI DGVa, and store the relevant data in DGV after strict quality control. The pipeline of the data construction is as follows
At present, the database contains more than 2 million genome structure variation information from 55 research projects, covering the results of a number of detection techniques, as shown in the following figure.
Through the search box on the front page, it is convenient to search. Taking CFTR as an example, the results are displayed in the gbrowser Genome browser as follows
The corresponding structural variation information for the region is given, the number from dbVar begins with nsv, and from DGVa begins with esv. The database contains the number beginning with dgv, as well as OMIM, DECIPHER, UCSC segmental duplication and other annotation information.
The length of the CNV included in the database is as follows
Most of them are concentrated in 1-10kb. As a control data set of normal sample CNV, when conducting disease-related CNV research, the database can remove the overlapping CNV and study the remaining patient-specific CNV.
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