What database is TSGene?
This article mainly introduces what TSGene is a database, has a certain reference value, interested friends can refer to, I hope you can learn a lot after reading this article, the following let the editor take you to understand it.
Tumor suppressor gene tumor suppressor gene, referred to as TSG, is a kind of genes that exist in normal cells, can inhibit cell growth and have potential anti-tumor effect. TSGene is a database of tumor suppressor genes collected from the literature.
The web address of the database is as follows
Https://bioinfo.uth.edu/TSGene/
The latest version is v2.0, which contains 1217 human TSGs, including 1018 protein-coding genes and 199lncRNA. At the same time, a variety of annotations have been made on these genes, including expression, mutation sites, protein-protein interactions and other annotated information. The details of genes can be retrieved through the Query menu on the official website. Take BRCA1 as an example, the results are as follows
1. General information
Contains the gene name, chromosome location, corresponding pathway and disease, sequence and other information, as shown below
2. Literature
The literature and abstract information related to the gene are shown as follows
3. Expression
Show the expression information of the gene in normal and diseased samples of different tumors, as well as the results of difference analysis, as shown below.
4. Regulation
Contains the following four types of regulatory information
The regulatory relationship between miRNA and this gene
The relationship between transcription factor and the regulation of this gene
Post-transcriptional modification of the gene
Methylation expression profile of the gene
Using the miRNA target gene information in the miRTarBase database, the miRNA regulatory network shown below is provided, as shown below.
The TransFac database is used to provide information on the transcription factors regulating the gene, as shown below.
The post-transcriptional modification information of the gene is provided using the Uniprot database, as shown below.
The expression profile information of the methylation site on the gene is provided by using DiseaseMeth database, which is illustrated as follows.
5. Variant
Using the COSMIC database, the information of somatic mutation and CNV site on the gene is provided. The results of somatic mutation are shown below.
6. Interaction
Provides information about gene interaction, which comes from multiple databases, as shown below
The information in the database is downloaded free of charge, and this database and ONGene database complement each other. For cancer research, both databases are worth referring to.
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