How to understand IMGT and HLA databases

In this issue, the editor will bring you about how to understand IMGT and HLA database. The article is rich in content and analyzed and described from a professional point of view. I hope you can get something after reading this article.

The IMGT/HLA database contains the sequence information of different Allel of HLA, which can be found at

Https://www.ebi.ac.uk/ipd/imgt/hla/

Last updated on July 11, 2018, version 3.33.0, the information included in the database is as follows

1. Data overview

The database mainly contains the Allel information of HLA I type and II type genes, as well as some Allel of non-HLA genes.

2. HLA I type

For HLA-I type genes, it contains classic HLA-A, HLA-B, HLA-C and other genes, in addition, there are some pseudogenes.

3. HLA II type

HLA II type genes mainly contain DR, DQ, DP, DO and DM genes.

4. Other genes

Contains HFE, MICA, MICB, TAP1, TAP2 genes

For different Allel, in addition to the standard naming specified by the WHO committee, a HLA number is provided, as shown in the following diagram

In the link below, you can view the details of each allel

Https://www.ebi.ac.uk/ipd/imgt/hla/docs/version_r3330.html

The underlined are all hyperlinks, you can click to see the details. As an example, the details are as follows: Apati01VO1VO1VO1VO1VUR 14

The database also provides FTP services for downloading genes or protein sequences of different Allel, with the following links

Ftp://ftp.ebi.ac.uk/pub/databases/ipd/imgt/hla/

In FTP, it provides fasta, msf, pir and other formats. You can usually download fasta, and provide dna, rna, and protein sequences at three different levels.

The above is the editor for you to share how to understand IMGT and HLA database, if you happen to have similar doubts, you might as well refer to the above analysis to understand. If you want to know more about it, you are welcome to follow the industry information channel.