What kind of database is TSNAdb?

This article mainly introduces what TSNAdb is a database, has a certain reference value, interested friends can refer to, I hope you can learn a lot after reading this article, the following let the editor take you to understand it.

TSNAdb is a database of new tumor specific antigens. Somatic mutation and HLA alleles information of 7748 tumor samples from 16 kinds of tumors were collected from TCGA and TCIA databases, and then NetMHCpan v2.8 and NetMHCpan v4.0 software were used to predict the affinity between mutated peptides and HLA.

The web address of the database is as follows

Http://biopharm.zju.edu.cn/tsnadb

The pipeline built is shown below

On the basis of the original analysis results, the functions of browsing, retrieval, verification and download are provided.

1. Browser

To view the related new tumor antigens through the gene name, you can specify the analysis software and tumor type. The search box is shown below.

The results are as follows

2. Search

Search by gene name, the search box is as follows

The search results are displayed as a heat map, as shown below

Each cell in the heat map represents the binding affinity between the mutated peptide and HLA alleles, the affinity changes from low to high, the color transitions from yellow to red, the colored cell represents a new tumor antigen, and the mouse hovers over the corresponding cell to display specific information such as mutation, HLA Allel, affinity value and so on.

3. Validation

The affinity data of peptides and HLA provided in IEDB database are used to verify the results.

4. Download

Separate the analysis results according to different tumor types, as shown below

Through TSNAdb, we can quickly search for new tumor antigens and analyze and find new antigens shared in many kinds of tumors, which is helpful to find new targets of immunotherapy.

Thank you for reading this article carefully. I hope the article "what is a database of TSNAdb" shared by the editor will be helpful to you. At the same time, I also hope you will support us and pay attention to the industry information channel. More related knowledge is waiting for you to learn!