What is the use of TransmiR database

This article will explain in detail what is the use of TransmiR database for you. The editor thinks it is very practical, so I share it with you as a reference. I hope you can get something after reading this article.

MRNA can be translated into proteins with various functions, one of which is very popular in the study of regulatory proteins, that is, transcription factor transcription factor, referred to as TF,TF, is involved in the regulation of transcriptional initiation, which is an indispensable link in the study of transcriptional regulation. MiRNA can bind to mRNA and play a post-transcriptional regulatory function. Both of them are important components of the regulatory network in organisms.

As for the regulation relationship in vivo, more research is focused on the regulation between TF-mRNA and miRNA-mRNA. In fact, TF can also regulate the transcriptional process of miRNA, and TransmiR is a database of regulatory relationships between transcription factors and miRNA collated from the literature.

Http://www.cuilab.cn/transmir

In this database, the evidence supporting Tf-miRNA is divided into the following three categories

Level1

Level2

Literature

The amount of data at all levels of evidence is as follows

The database covers the TF-miRNA information of multiple species, and the corresponding amount of data for each species is as follows.

Through the Search function of the official website, you can search according to miRNA or TF, as shown below

Click the corresponding TF and miRNA to view the details. The miRNA diagram is as follows

The database was developed by the same team as HMDD, so miRNA-related disease information is integrated into the data.

Through the Network function, you can view the network diagram of the TF-miRNA regulation relationship, as shown below

The official website also provides a predict function to predict the regulatory relationship between the specified TF and miRNA, as shown below

According to the motif information corresponding to TF, look for the miRNA near the potential binding site.

The information of this database can be downloaded free of charge. Through this database, the regulation relationship of TF-miRNA can be studied conveniently.

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