What is the use of HMDD database

This article is to share with you about the use of HMDD databases. The editor thinks it is very practical, so share it with you as a reference and follow the editor to have a look.

HMDD is a database of miRNA associated with diseases collected by hand, the latest version is V3.0, and the website is as follows

Http://www.cuilab.cn/hmdd

A total of 1102 miRNA genes, 850 diseases, 32281 miRNA and disease association data, for each miRNA and disease association, there is a corresponding literature, will give pubmed ID.

Through the Browse function, you can view the contents of the database from the perspective of miRNA and disease

1. MiRNA

The results of hsa-let-7 are as follows

2. Disease

The results of Anemia's disease are as follows

Deal with the association between miRNA and disease, use the data in the literature, sort out the target gene data corresponding to miRNA, and provide the network diagram of miRNA-target gene, which can not only analyze the regulatory network of a single miRNA, but also support the regulatory network of miRNA in a disease, as shown below.

The legend is as follows

Blue nodes represent gene, other color nodes represent miRNA, green indicates that the miRNA is up-regulated in patients, red represents down-regulation, gray represents the expression trend of uncertain miRNA, red connection represents negative regulation, and green connection represents positive regulation.

The data in this database can be downloaded for free, and through this database, we can quickly get the association between miRNA and disease.

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