Shulou(Shulou.com)12/24 Report--

CTOnews.com, December 19, DNA is the cornerstone of life, made up of the letters A, T, G and C or nucleotides. Scientists have long hoped to master the "DNA building block" technology to create an effective artificial DNA.

The team at the Scargus School of Pharmaceutical and Pharmaceutical Sciences at the University of California, San Diego has taken another step towards this goal by creating DNA with new nucleotides and by producing specific proteins to develop entirely new drugs for certain diseases.

Dr Dong Wang, senior author of the study, explained that this opened a new door to the creation of artificial DNA, showing a variety of potentially important uses.

The project is led by Wang, Dr. Steven A. Benner and Dr. Dmitry Lyumkis. Together, the three authors show that not only can you create artificial DNA, but artificial nucleotides can also help create customized proteins that we can use to target specific diseases that are difficult to fight.

CTOnews.com note: the four nucleotides that make up DNA are adenine (A), thymine (T), guanine (G) and cytosine (C).

In DNA molecules, the base pairs formed by nucleotides have unique molecular geometry, called Watson and Crick geometry (Watson-Crick), named after the scientist who discovered the double helix structure of DNA in 1953.

The new study uses the artificial extended genetic Information system (AEGIS), which contains two new base pairs. By isolating RNA polymerase from bacteria and testing their interaction with synthetic base pairs, scientists formed a Watson and Crick geometry similar to natural base pairs.

The results show that the enzymes that transcribe DNA cannot tell the difference between these synthetic base pairs and those found in nature.

CTOnews.com attached the reference address of the paper: Oh, J., Shan, Z., Hoshika, S. et al. A unified Watson-Crick geometry drives transcription of six-letter expanded DNA alphabets by E. Coli RNA polymerase. Nat Commun 14, 8219 (2023). Https://doi.org/10.1038/s41467-023-43735-9 .

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